- London Sunday Times Article - 'Beating Scoliosis'
2022:
The axonemal dynein heavy chain 10 gene is essential for monocilia motility and spine alignment in zebrafish. Wang Y, Troutwine BR, Zhang H, Gray RS. Dev Biol. 2022 Feb;482:82-90. Epub 2021 Dec 13. PMID: 34915022
2021:
A G protein-coupled receptor is required in cartilaginous and dense connective tissues to maintain spine alignment. Liu Z, Hussien AA, Wang Y, Heckmann T, Gonzalez R, Karner CM, Snedeker JG, Gray RS. Elife. 2021 Jul 28;10:e67781. doi: 10.7554/eLife.67781. PMID: 34318745
2020:
Mutations in KIF7 Implicated in Idiopathic Scoliosis in Humans and Axial Curvatures in Zebrafish. Terhune EA, Cuevas MT, Monley AM, Wethey CI, Chen X, Cattel MV, Bayrak MN, Bland MR, Sutphin B, Devon Trahan G, Taylor MRG, Niswander LA, Jones KL, Baschal EE, Antunes L, Dobbs M, Gurnett C, Appel B, Gray R, Miller NH. Hum Mutat. 2020 Dec 31. doi: 10.1002/humu.24162. PMID: 33382518.
Postembryonic screen for mutations affecting spine development in zebrafish.
Gray RS, Gonzalez R, Ackerman SD, Minowa R, Griest JF, Bayrak MN, Troutwine B, Canter S, Monk KR, Sepich DS, Solnica-Krezel L. Dev Biol. 2020 Dec 5;471:18-33. doi: 10.1016/j.ydbio.2020.11.009. Online ahead of print. PMID: 33290818
Coding Variants Coupled With Rapid Modeling in Zebrafish Implicate Dynein Genes, dnaaf1 and zmynd10, as Adolescent Idiopathic Scoliosis Candidate Genes. Wang Y, Liu Z, Yang G, Gao Q, Xiao L, Li J, Guo C, Troutwine BR, Gray RS, Xie L, Zhang H. Front Cell Dev Biol. 2020 Nov 4;8:582255. doi: 10.3389/fcell.2020.582255. eCollection 2020. PMID: 33251213
Genomic characterization of the adolescent idiopathic scoliosis associated transcriptome and regulome.
Makki N, Zhao J, Liu Z, Eckalbar WL, Ushiki A, Khanshour AM, Wu J, Rios J, Gray RS, Wise CA, Ahituv N. Hum Mol Genet. 2020 Nov 12:ddaa242. doi: 10.1093/hmg/ddaa242. Online ahead of print. PMID: 33179741
Development of a straight vertebrate body axis. Bagnat M, Gray RS. Development. 2020 Oct 6;147(21):dev175794. doi: 10.1242/dev.175794. PMID: 33023886
The developmental biology of kinesins.
Konjikusic MJ, Gray RS, Wallingford JB. Dev Biol. 2020 Sep 19:S0012-1606(20)30257-8. doi: 10.1016/j.ydbio.2020.09.009. Online ahead of print. PMID: 32961118
The Reissner Fiber Is Highly Dynamic In Vivo and Controls Morphogenesis of the Spine.
Troutwine BR, Gontarz P, Konjikusic MJ, Minowa R, Monstad-Rios A, Sepich DS, Kwon RY, Solnica-Krezel L, Gray RS. Curr Biol. 2020 Jun 22;30(12):2353-2362.e3. doi: 10.1016/j.cub.2020.04.015. Epub 2020 May 7. PMID: 32386529
The cartilage matrisome in adolescent idiopathic scoliosis.
Wise CA, Sepich D, Ushiki A, Khanshour AM, Kidane YH, Makki N, Gurnett CA, Gray RS, Rios JJ, Ahituv N, Solnica-Krezel L. Bone Res. 2020 Mar 9;8:13. doi: 10.1038/s41413-020-0089-0. eCollection 2020. PMID: 32195011
A comparative study of the turnover of multiciliated cells in the mouse trachea, oviduct, and brain.
Roberson EC, Tran NK, Konjikusic MJ, Fitch RD, Gray RS, Wallingford JB. Dev Dyn. 2020 Jul;249(7):898-905. doi: 10.1002/dvdy.165. Epub 2020 Mar 12. PMID: 32133718
Gray RS, Gonzalez R, Ackerman SD, Minowa R, Griest JF, Bayrak MN, Troutwine B, Canter S, Monk KR, Sepich DS, Solnica-Krezel L. Dev Biol. 2020 Dec 5;471:18-33. doi: 10.1016/j.ydbio.2020.11.009. Online ahead of print. PMID: 33290818
Coding Variants Coupled With Rapid Modeling in Zebrafish Implicate Dynein Genes, dnaaf1 and zmynd10, as Adolescent Idiopathic Scoliosis Candidate Genes. Wang Y, Liu Z, Yang G, Gao Q, Xiao L, Li J, Guo C, Troutwine BR, Gray RS, Xie L, Zhang H. Front Cell Dev Biol. 2020 Nov 4;8:582255. doi: 10.3389/fcell.2020.582255. eCollection 2020. PMID: 33251213
Genomic characterization of the adolescent idiopathic scoliosis associated transcriptome and regulome.
Makki N, Zhao J, Liu Z, Eckalbar WL, Ushiki A, Khanshour AM, Wu J, Rios J, Gray RS, Wise CA, Ahituv N. Hum Mol Genet. 2020 Nov 12:ddaa242. doi: 10.1093/hmg/ddaa242. Online ahead of print. PMID: 33179741
Development of a straight vertebrate body axis. Bagnat M, Gray RS. Development. 2020 Oct 6;147(21):dev175794. doi: 10.1242/dev.175794. PMID: 33023886
The developmental biology of kinesins.
Konjikusic MJ, Gray RS, Wallingford JB. Dev Biol. 2020 Sep 19:S0012-1606(20)30257-8. doi: 10.1016/j.ydbio.2020.09.009. Online ahead of print. PMID: 32961118
The Reissner Fiber Is Highly Dynamic In Vivo and Controls Morphogenesis of the Spine.
Troutwine BR, Gontarz P, Konjikusic MJ, Minowa R, Monstad-Rios A, Sepich DS, Kwon RY, Solnica-Krezel L, Gray RS. Curr Biol. 2020 Jun 22;30(12):2353-2362.e3. doi: 10.1016/j.cub.2020.04.015. Epub 2020 May 7. PMID: 32386529
The cartilage matrisome in adolescent idiopathic scoliosis.
Wise CA, Sepich D, Ushiki A, Khanshour AM, Kidane YH, Makki N, Gurnett CA, Gray RS, Rios JJ, Ahituv N, Solnica-Krezel L. Bone Res. 2020 Mar 9;8:13. doi: 10.1038/s41413-020-0089-0. eCollection 2020. PMID: 32195011
A comparative study of the turnover of multiciliated cells in the mouse trachea, oviduct, and brain.
Roberson EC, Tran NK, Konjikusic MJ, Fitch RD, Gray RS, Wallingford JB. Dev Dyn. 2020 Jul;249(7):898-905. doi: 10.1002/dvdy.165. Epub 2020 Mar 12. PMID: 32133718
2019:
Regulation of terminal hypertrophic chondrocyte differentiation in Prmt5 mutant mice modeling infantile idiopathic scoliosis.
Liu Z, Ramachandran J, Vokes SA, Gray RS. Dis Model Mech. 2019 Dec 17;12(12). pii: dmm041251. doi:
10.1242/dmm.041251. PubMed PMID: 31848143.
Liu Z, Ramachandran J, Vokes SA, Gray RS. Dis Model Mech. 2019 Dec 17;12(12). pii: dmm041251. doi:
10.1242/dmm.041251. PubMed PMID: 31848143.
Zebrafish: An Emerging Model for Orthopedic Research.Busse B, Galloway JL, Gray RS, Harris MP, Kwon RY. J Orthop Res. 2019 Nov 26. doi: 10.1002/jor.24539.
[Epub ahead of print] Review. PubMed PMID: 31773769.
Dysregulation of STAT3 signaling is associated with endplate-oriented herniations of the intervertebral disc in Adgrg6 mutant mice.Liu Z, Easson GWD, Zhao J, Makki N, Ahituv N, Hilton MJ, Tang SY, Gray RS. PLoS Genet. 2019 Oct 25;15(10):e1008096. doi: 10.1371/journal.pgen.1008096. eCollection 2019 Oct. PMID:31652254.
PRMT5 is necessary to form distinct cartilage identities in the knee and long bone.
Ramachandran J, Liu Z, Gray RS, Vokes SA. Dev Biol. 2019 Dec
15;456(2):154-163. doi: 10.1016/j.ydbio.2019.08.012. Epub 2019 Aug 20. PubMed
PMID: 31442442; PubMed Central PMCID: PMC6884688.
The expanding functional roles and signaling mechanisms of adhesion G protein-coupled receptors.
Morgan RK, Anderson GR, Araç D, Aust G, Balenga N, Boucard A, Bridges JP,
Engel FB, Formstone CJ, Glitsch MD, Gray RS, Hall RA, Hsiao CC, Kim HY, Knierim
AB, Kusuluri DK, Leon K, Liebscher I, Piao X, Prömel S, Scholz N, Srivastava S,
Thor D, Tolias KF, Ushkaryov YA, Vallon M, Van Meir EG, Vanhollebeke B, Wolfrum
U, Wright KM, Monk KR, Mogha A. Ann N Y Acad Sci. 2019
Nov;1456(1):5-25. doi: 10.1111/nyas.14094. Epub 2019 Jun 6. PubMed PMID:
31168816.
[Epub ahead of print] Review. PubMed PMID: 31773769.
Dysregulation of STAT3 signaling is associated with endplate-oriented herniations of the intervertebral disc in Adgrg6 mutant mice.Liu Z, Easson GWD, Zhao J, Makki N, Ahituv N, Hilton MJ, Tang SY, Gray RS. PLoS Genet. 2019 Oct 25;15(10):e1008096. doi: 10.1371/journal.pgen.1008096. eCollection 2019 Oct. PMID:31652254.
PRMT5 is necessary to form distinct cartilage identities in the knee and long bone.
Ramachandran J, Liu Z, Gray RS, Vokes SA. Dev Biol. 2019 Dec
15;456(2):154-163. doi: 10.1016/j.ydbio.2019.08.012. Epub 2019 Aug 20. PubMed
PMID: 31442442; PubMed Central PMCID: PMC6884688.
The expanding functional roles and signaling mechanisms of adhesion G protein-coupled receptors.
Morgan RK, Anderson GR, Araç D, Aust G, Balenga N, Boucard A, Bridges JP,
Engel FB, Formstone CJ, Glitsch MD, Gray RS, Hall RA, Hsiao CC, Kim HY, Knierim
AB, Kusuluri DK, Leon K, Liebscher I, Piao X, Prömel S, Scholz N, Srivastava S,
Thor D, Tolias KF, Ushkaryov YA, Vallon M, Van Meir EG, Vanhollebeke B, Wolfrum
U, Wright KM, Monk KR, Mogha A. Ann N Y Acad Sci. 2019
Nov;1456(1):5-25. doi: 10.1111/nyas.14094. Epub 2019 Jun 6. PubMed PMID:
31168816.
2018:
Mutations in Kinesin family member 6 reveal specific role in ependymal cell ciliogenesis and human neurological development
Konjikusic MJ, Yeetong P, Boswell CW, Lee C, Roberson EC, Ittiwut R, Suphapeetiporn K, Ciruna B, Gurnett CA, Wallingford JB, Shotelersuk V, Gray RS. PLoS Genet. 2018 Nov 26;14(11):e1007817. doi: 10.1371/journal.pgen.1007817. PMID:30475797.
Biomechanical interplay between anisotropic re-organization of cells and the surrounding matrix underlies transition to invasive cancer spread. Kim DH, Ewald AJ, Park J, Kshitiz, Kwak M, Gray RS, Su CY, Seo J, An SS, Levchenko A.Sci Rep. 2018 Sep 21;8(1):14210. doi: 10.1038/s41598-018-32010-3.PMID:30242256
A missense variant in SLC39A8 is associated with severe idiopathic scoliosis.
Haller G, McCall K, Jenkitkasemwong S, Sadler B, Antunes L, Nikolov M, Whittle J, Upshaw Z, Shin J, Baschal E, Cruchaga C, Harms M, Raggio C, Morcuende JA, Giampietro P, Miller NH, Wise C, Gray RS, Solnica-Krezel L, Knutson M, Dobbs MB, Gurnett CA.Nat Commun. 2018 Oct 9;9(1):4171. doi: 10.1038/s41467-018-06705-0.PMID:30301978
Liu Z., Gray R.S. (2018) Animal Models of Idiopathic Scoliosis. In: Kusumi K., Dunwoodie S. (eds) The Genetics and Development of Scoliosis. Springer, Cham
Summary of the first inaugural joint meeting of the International Consortium for scoliosis genetics and the International Consortium for vertebral anomalies and scoliosis, March 16-18, 2017, Dallas, Texas.
Giampietro PF, Pourquie O, Raggio C, Ikegawa S, Turnpenny PD, Gray R, Dunwoodie SL, Gurnett CA, Alman B, Cheung K, Kusumi K, Hadley-Miller N, Wise CA. Am J Med Genet A. 2018 Jan;176(1):253-256. doi: 10.1002/ajmg.a.38550. Epub 2017 Nov 21.PMID:29159998
Konjikusic MJ, Yeetong P, Boswell CW, Lee C, Roberson EC, Ittiwut R, Suphapeetiporn K, Ciruna B, Gurnett CA, Wallingford JB, Shotelersuk V, Gray RS. PLoS Genet. 2018 Nov 26;14(11):e1007817. doi: 10.1371/journal.pgen.1007817. PMID:30475797.
Biomechanical interplay between anisotropic re-organization of cells and the surrounding matrix underlies transition to invasive cancer spread. Kim DH, Ewald AJ, Park J, Kshitiz, Kwak M, Gray RS, Su CY, Seo J, An SS, Levchenko A.Sci Rep. 2018 Sep 21;8(1):14210. doi: 10.1038/s41598-018-32010-3.PMID:30242256
A missense variant in SLC39A8 is associated with severe idiopathic scoliosis.
Haller G, McCall K, Jenkitkasemwong S, Sadler B, Antunes L, Nikolov M, Whittle J, Upshaw Z, Shin J, Baschal E, Cruchaga C, Harms M, Raggio C, Morcuende JA, Giampietro P, Miller NH, Wise C, Gray RS, Solnica-Krezel L, Knutson M, Dobbs MB, Gurnett CA.Nat Commun. 2018 Oct 9;9(1):4171. doi: 10.1038/s41467-018-06705-0.PMID:30301978
Liu Z., Gray R.S. (2018) Animal Models of Idiopathic Scoliosis. In: Kusumi K., Dunwoodie S. (eds) The Genetics and Development of Scoliosis. Springer, Cham
Summary of the first inaugural joint meeting of the International Consortium for scoliosis genetics and the International Consortium for vertebral anomalies and scoliosis, March 16-18, 2017, Dallas, Texas.
Giampietro PF, Pourquie O, Raggio C, Ikegawa S, Turnpenny PD, Gray R, Dunwoodie SL, Gurnett CA, Alman B, Cheung K, Kusumi K, Hadley-Miller N, Wise CA. Am J Med Genet A. 2018 Jan;176(1):253-256. doi: 10.1002/ajmg.a.38550. Epub 2017 Nov 21.PMID:29159998
2017:
Dynein/dynactin is necessary for anterograde transport of Mbp mRNA in oligodendrocytes and for myelination in vivo. Herbert AL, Fu M, Drerup CM, Gray RS, Harty BL, Ackerman SL, O'Reily-Pol T, Johnson SL, Nechiporuk AV, Barres BA, and Monk KR. Proceedings of the National Academy of Sciences. 2017 Oct 24;114(43):E9153-E9162.
Whole Genome Sequencing-Based Mapping and Candidate Identification of Mutations from Fixed Zebrafish Tissue. Sanchez NE, Harty BL, O'Reilly-Pol T, Ackerman SD, Herbert AL, Holmgren M, Johnson SL, Gray RS, Monk KR. G3. 2017; https://doi.org/10.1534/g3.117.300212. PMID:28855284.
Whole Genome Sequencing-Based Mapping and Candidate Identification of Mutations from Fixed Zebrafish Tissue. Sanchez NE, Harty BL, O'Reilly-Pol T, Ackerman SD, Herbert AL, Holmgren M, Johnson SL, Gray RS, Monk KR. G3. 2017; https://doi.org/10.1534/g3.117.300212. PMID:28855284.
2015:
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Gpr126/Adgrg6 deletion in cartilage models idiopathic scoliosis and pectus excavatum in mice.
Karner CM, Long F, Solnica-Krezel L, Monk KR, Gray RS. Hum Mol Genet. 2015 Aug 1;24(15):4365-73. PMID:25954032 |
2014:
Kinesin family member 6 (kif6) is necessary for spine development in zebrafish.
Buchan JG, Gray RS, Gansner JM, Alvarado DM, Burgert L, Gitlin JD, Gurnett CA, Goldsmith MI.
Dev Dyn. 2014 Dec;243(12):1646-57. PMID:25283277
A temporal requirement for Hippo signaling in mammary gland differentiation, growth, and tumorigenesis.
Chen Q, Zhang N, Gray RS, Li H, Ewald AJ, Zahnow CA, Pan D.
Genes Dev. 2014 Mar 1;28(5):432-7. PMID:24589775
Loss of col8a1a function during zebrafish embryogenesis results in congenital vertebral malformations.
Gray RS, Wilm TP, Smith J, Bagnat M, Dale RM, Topczewski J, Johnson SL, Solnica-Krezel L.
Dev Biol. 2014 Feb 1;386(1):72-85. PMID:24333517
Buchan JG, Gray RS, Gansner JM, Alvarado DM, Burgert L, Gitlin JD, Gurnett CA, Goldsmith MI.
Dev Dyn. 2014 Dec;243(12):1646-57. PMID:25283277
A temporal requirement for Hippo signaling in mammary gland differentiation, growth, and tumorigenesis.
Chen Q, Zhang N, Gray RS, Li H, Ewald AJ, Zahnow CA, Pan D.
Genes Dev. 2014 Mar 1;28(5):432-7. PMID:24589775
Loss of col8a1a function during zebrafish embryogenesis results in congenital vertebral malformations.
Gray RS, Wilm TP, Smith J, Bagnat M, Dale RM, Topczewski J, Johnson SL, Solnica-Krezel L.
Dev Biol. 2014 Feb 1;386(1):72-85. PMID:24333517